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Ketamine nasal spray the drug is a form of ketamine, a generic drug that’s been used as a form of anesthesia for many years, Dr. Anand says. Ketamine nasal spray is a mist that is compounded by a specialty pharmacy for those who have been approved to use it. Ketamine nasal spray works like other nasal mists you have used, such as those for allergies, in terms of getting it into your body. However, Ketamine, which is known to have lasting effects on depression and chronic pain, is in the spray, and it is designed to provide the user with relief from these and other conditions. While Ketamine is known for its abuse as a club drug in the past, there are studies showing that low doses of Ketamine, such as those found in Ketamine nasal spray, can actually help improve symptoms of chronic pain and several different mood disorders, making it an increasingly popular form of treatment.
Ketamine has also been used for years in smaller doses in IV form for patients with treatment-resistant depression. But as a generic drug, it has not been put through the FDA’s review process for that use.
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It’s actually a controlled substance (it is sometimes abused as a recreational drug — you may have heard it called Special K). Because of that, and because it can create feelings of dissociation and hallucination in people who take it, the new esketamine nasal spray will only be administered in a doctor’s office or hospital setting.
“It’s a slightly different form of ketamine and will be given as nasal puffs, but the effects are essentially the same,” Dr. Anand says.
A patient will go to their doctor once or twice a week to get nasal puffs of a dose of ketamine. Because they may experience disorientation or confusion immediately afterward, they will stay at the doctor’s office for two hours. They are also advised not to drive, operate machinery, or undertake a task that requires similar mental effort for the rest of the day.
Esketamine nasal spray appears both effective and fast-acting for treatment-resistant depression,
Why is Ketamine nasal spray promising
One potential benefit of the new drug is that it’s fast-acting. People may notice a relief in symptoms within just a few hours, and it could last for several days, Dr. Anand says. Most oral antidepressants, on the other hand, can take weeks to start working.
That’s because it works in a different way from other depression drugs. “Whereas most other available antidepressants work mainly on the serotonin, norepinephrine or dopamine systems, ketamine has major effects on glutamate, which is a different neurotransmitter that is much more prevalent in the brain,” Dr. Anand says.
Side Effects
Dizziness, dissociation, dysgeusia (change or distortion in sense of taste), vertigo, and nausea were the most common side effects of the drug. Most tended to occur shortly after dosing and cleared up within 90 minutes. However, the consensus of the study was that overall the drug was safe and tolerable.
An imperfect solution
Beyond potential side effects, ketamine does have additional drawbacks. Though it has been used safely as a short-term anesthetic and in lower doses as a short-term antidepressant, doctors don’t yet understand whether it’s safe and effective to use over many months or years.
“This drug affects a major neurochemical in the brain, and if you interfere with that long-term, we’re not sure what the effects of that are going to be,” Dr. Anand says. “It’s also a drug of addiction, and people can misuse it or overuse it.”
There’s also no guarantee that it will work in all groups of people with treatment-resistant depression. And, like other antidepressants, there’s always the chance that it could make symptoms worse.
Esketamine was studied in five clinical trials leading up to its approval. Only one short-term trial, and its follow-up, longer-term relapse prevention trial of patients who had benefited from ketamine, produced positive results that were statistically significant, Dr. Anand says. Another study focused solely on adults over age 65 and found that benefit of treatment with antidepressants plus ketamine in that group of patients did not reach statistical significance.
Ketamine nasal spray, which is soon to be approved by the Food and Drug Administration as one of the first new treatments to battle conditions such as depression in almost thirty years, is becoming more and more popular today. Ketamine nasal spray is a groundbreaking new therapy that is great for people who have found that they are no longer responding to traditional therapies, or if they are hoping to try something new instead of potentially addictive medications.
What Types of Conditions Can Be Treated with Ketamine Nasal Spray?
Ketamine nasal spray can be used to treat several conditions, such as chronic pain and mood disorders. With some of the newer research being done on the positive effects of Ketamine for different conditions, it will undoubtedly be available as a treatment for a wider range of conditions soon. Currently, Ketamine nasal spray is used to treat the following:
- Chronic neuropathic pain
- Severe depression
- Suicidal thoughts or tendencies
- Post Traumatic Stress Disorder (PTSD)
- Obsessive Compulsive Disorder (OCD)
- Bipolar Disorder
Science Behind taking Ketamine Nasally
When it comes to using Ketamine nasal spray, it is important to understand the science behind it. Ketamine works by targeting damaged nerves and pathways within the brain, and changes them – it can change how the user feels pain and works to create positive effects on mood disorders, thus helping to alleviate depression or symptoms of conditions such as PTSD and OCD. While Ketamine nasal spray doesn’t deliver as high of a dosage as Ketamine infusions will, side effects are minimal and the user typically feels no negative effects from the Ketamine.
What to Expect from Ketamine Nasal Spray
Before you start on your treatment with Ketamine nasal spray, you will first need to find out if you are a proper candidate for the treatment. This involves screening and clearances from your psychiatrist or specialists, such as a GI specialist. If you are using Ketamine nasal spray for chronic pain, you will need to bring along any imaging or documents from your current physicians. If you are seeing a specialist, especially for liver conditions, you will need to get clearance from them prior to starting treatments, as it can cause a temporary slight increase in liver enzyme levels.
When you begin treatment with Ketamine nasal spray, you will be shown how to use the spray each day. As a saline spray with the drug suspended in it, it is easy to administer the spray yourself. The most common dosage of the medication is 100mg/ml.
Side Effects of Ketamine Nasal Spray
Side effects of Ketamine nasal spray tend to be minimal, and can include:
- Headaches
- Nausea
- Sedation
- Dizziness
- Liver enzyme elevation
Side effects tend to be mild to moderate.
Results and Follow-Up Care
When you start your treatment with Ketamine nasal spray, you will need to be seen in the office by your doctor at least once per month. If you are taking the nasal spray for depression or mood disorders, a follow up with your psychiatrist is required. This allows your doctors to track your progress of the Ketamine and how well you are doing with it. If you are under the care of a specialist, such as for a liver condition, you will need to see them as well to make sure your liver enzyme levels are remaining at an acceptable level.
Benefits of Using Nasal Ketamine Buy esketamine Nasal Spray
Ketamine nasal spray is incredibly helpful for treating and managing conditions, whether they be mood disorders or chronic neuropathic pain. Nasal Ketamine has a rapid onset of action, making it fast acting. It is a good rescue medication for fast pain relief, and it can really help you get back to living your best life.
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